APOLLO: Acute PresentatiOn of CoLorectaL Cancer: an internatiOnal snapshot: An international, multi-centre study of emergency presentations of colorectal cancer

Trial Overview

Acronym	APOLLO
Number	v1.0
Protocol Link	https://clinicaltrials.gov/ct2/show/NCT05641129?term=APOLLO+colorectal+cancer&draw=2&rank=1
Published Results Link	https://onlinelibrary.wiley.com/doi/10.1002/wjs.70106; https://www.sciencedirect.com/science/article/pii/S0039606025008165; https://journals.lww.com/dcrjournal/abstract/2025/12000/global_use_and_outcomes_of_endoscopic_stenting_in.17.aspx
Status	Open/recruiting
Category	Colorectal Cancer - All
Treatment Course	Surgery

Trial Description

Describe the variation in the operative and non-operative management of emergency presentations of colon and rectal cancer in an international cohort. Secondary aim is to identify risk factors for mortality (intraoperatively, at 30-days and at 90-days) and ostomy rates (at 30- and 90-days) in patients deemed for active management (i.e., not for palliative management) to develop a risk prediction model

Chief Investigator

EuroSurg Collaborative
Mx

Profile Link

Lead Centre

University of Birmingham
97 Vincent Drive
Birmingham, United Kingdom
B15 2SQ
United Kingdom

Website

Additional Information

Full Research Summary

Objective:	Primary aim: Describe the variation in the operative and non-operative management of emergency presentations of colon and rectal cancer in an international cohort. Secondary aims: Identify risk factors for mortality (intraoperatively, at 30-days and at 90-days) and ostomy rates (at 30- and 90-days) in patients deemed for active management (i.e., not for palliative management) to develop a risk prediction model Validate risk criteria of large bowel obstruction in patients with previously known colorectal cancer undergoing neoadjuvant chemotherapy or awaiting elective surgery
Aim:	Primary aim: Describe the variation in the operative and non-operative management of emergency presentations of colon and rectal cancer in an international cohort.
Methods:	APOLLO is an international, multi-centre, prospective observational study of acutely presenting colorectal cancer. This study will adapt the student- and trainee-led collaborative research model. APOLLO is open to any secondary or tertiary hospitals across the world with a general or colorectal surgery department performing major colorectal cancer surgery. All participating centres will be required to register the study according to local regulations, evidence of which must be uploaded onto REDCap prior to the commencement of data collection from each respective site. As this is an audit of practice, no change to normal patient management is required. Collaborators at each participating centre will prospectively collect data for all eligible patients over minimum 6-week periods from January to June 2023. Sites can contribute in multiple 6-week periods, providing they are not overlapping. There will be a rolling start date from 16 January, 2023 to 1 May, 2023. The last date a patient can be recruited is the 13 June. All 90-day follow-up should be completed by 11 September, 2023. Recruitment dates may be extended at the discretion of the steering committee, allowing for extensions if there are delays in site initiation.
Reason for International Trial:	To capture international variation in practice