Genetics

Free paper - Francisco Lopez-Kostner at ESCP Sorrento 2010

ESCP/EHTG Symposium - Anna Lepistö (Finland) at ESCP Barcelona 2021

ESCP/EHTG Symposium - Gloria Zaffaroni (Italy) at ESCP Barcelona 2021

Guideline session - Gloria Zaffaroni (Italy) at ESCP Dublin 2022

Oral poster - Yuri Chubarov at ESCP Vienna 2012

Oral Poster (Neoplasia) - Gabriela Möslein at ESCP Dublin 2015

ESCP/EAES Symposium - Francesco Bianco (Italy) at ESCP Berlin 2017

ESCP/EAES Symposium - Gabriela Möslein (Germany) at ESCP Berlin 2017

Oral poster - Ashish Sinha at ESCP Sorrento 2010

ESCP/EHTG joint symposium - Alessandro Manucci (Italy) at ESCP Vilnius 2023

International Fellow Free Papers - Chul Seung Lee (Korea) at ESCP Dublin 2022

ESCP/EHTG Symposium - Sanne ten Broeke (The Netherlands) at ESCP Vienna 2019

Oral Poster (Neoplasia) - Mattias Prytz at ESCP Barcelona 2014

ESCP/EHTG Symposium - Julian Sampson (UK) at ESCP Vienna 2019

Education session - Ash Sinha (UK) & Kirsten De Burlet (UK) at ESCP Thessaloniki 2024

Short Paper - James Park (UK) at Tripartite Colorectal Meeting 2014

Oral poster - Min Hoe Chew at ESCP Vienna 2012

ESCP Guidelines Update - Gabriela Möslein (Germany) at ESCP Berlin 2017

Symposium - Graham Williams at ESCP Barcelona 2014

Symposium - Yann Parc at ESCP Barcelona 2014

ESCP/EHTG Symposium - Magnus von Knebel Doeberitz (Germany) at ESCP Vienna 2019

Oral Poster (Functional) - Farouk Drissi at ESCP Dublin 2015

Symposium - John Burn (UK) at ESCP Nice 2018

Symposium - Matthias Kloor (Germany) at ESCP Nice 2018

Symposium - Toni Seppälä (Finland) at ESCP Nice 2018

One of 12 best abstracts - Toritseju Sillo (UK) at ESCP Dublin 2022

ESCP/EHTG Symposium - Julian Sampson (UK) at ESCP Vienna 2019

Keynote lecture - Jean-Pierre Hugot at ESCP Belgrade 2013

The two main inherited colorectal cancer syndromes are familial adenomatous polyposis (FAP) and Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), which account for less than 1 % and 3 % of colorectal cancers, respectively. FAP is characterized by the occurrence of multiple colorectal adenomas that often start to develop during the teenage years. A germ-line mutation in the APC gene located on chromosome 5 is found in about 85 % of patients with this phenotype. Without prophylactic surgery, nearly all will develop colorectal cancer. Surgery, including restorative proctocolectomy or total colectomy with ileorectal anastomosis, has greatly reduced the death rate from colorectal cancer, and now prognosis is dependent on desmoid tumors and duodenal polyposis.

HNPCC syndrome is more complex than FAP because more genes are involved, penetrance is less complete, and expression varies more. The recommendation is to try to determine the microsatellite instability (MSI) phenotype to test patients showing an MSI. Screening guidelines are well defined. Surgical management of HNPCC using segmental versus total colectomy is still debated.

A third syndrome, the MYH-associated polyposis syndrome, related to germ-line biallelic mutation of the human MUTYH gene, is an autosomal-recessive colon cancer syndrome. Other syndromes such as Peutz Jeghers syndrome, juvenile polyposis, and hyperplastic polyposis are seen less frequently.

ESCP/EHTG joint symposium - Julio Mayol (Spain) at ESCP Vilnius 2023