Following its suspension due to the Covid-19 pandemic earlier this year we are happy to announce the resumption of the EAGLE study. The study is still open to recruitment of new sites.

EAGLESites which were previously randomised prior to the study suspension have been contacted to determine their readiness to resume, and the first 14 recommenced the study at the end of July. A further 32 sites will resume at the end of August and we are currently planning for the randomisation of Phase 3 of the study.

Any sites which have begun their site registration form but have not yet completed it are asked to do so at their earliest convenience so that they can be randomised.

Please see below for further study information and contact This email address is being protected from spambots. You need JavaScript enabled to view it. with any questions or queries.

Study information

EAGLE is an international, multi-centre, cluster randomised-sequence service improvement study of the ESCP Safe-anastomosis Quality Improvement Intervention to reduce anastomotic leak following right colectomy and ileocaecal resection. Any hospital or surgical unit performing elective and/or emergency colorectal surgery may participate.

The study consists of interactive, online training modules for surgeons and theatre teams and will assess whether implementation of the ESCP safe-anastomosis intervention reduces risk of anastomotic leak rate.

The study programme has three main approaches:

  • Preoperative risk stratification - making sure for each patient that anastomosis is safe for them
  • Harmonisation of surgical technique - making the best anastomosis possible and checking it carefully after it is created
  • Implementation of an intra-operative, anastomosis ‘checklist’ - focusing the attention of the whole theatre team at this critical stage of the operation.

Overall, we hope to reach out to more than 2,000 surgeons at over 300 hospitals across the world, including 4,500 patients in total.

The primary outcome is the 30-day overall anastomotic leak rate, defined as clinical or radiologically detected anastomotic leak or intra-abdominal or pelvic collection.

More information about EAGLE and how to get involved here

ESCP Affiliates