TREC: Transanal endoscopic microsurgery (TEM) and Radiotherapy in Early rectal Cancer: a randomised phase II feasibility study
Trial Overview
| Acronym | TREC |
|---|---|
| Number | ISRCTN14422743 |
| Protocol Link | http://www.birmingham.ac.uk/Documents/college-mds/trials/bctu/trec/TREC-protocol-v1.pdf |
| Public Trial Registry Link | http://www.isrctn.com/ISRCTN14422743 |
| Status | Closed |
| Category | Colorectal Cancer - Rectal Specific |
| Treatment Course | Neoadjuvant |
Trial Description
| TREC will determine the feasibility of performing a randomised controlled trial (RCT) of radical total mesorectal excision (TME) surgery (current gold standard) versus short course pre-operative radiotherapy (SCPRT) and delayed local excision at 8 - 10 weeks for T1-2N0M0 rectal cancer defined according to both magnetic resonance imaging (MRI) and endorectal ultrasound (ERUS). |
Chief Investigator
|
Simon Bach Mr |
| Profile Link |
Lead Centre
|
University of Birmingham Birmingham B15 2TT Birmingham B15 2TT UK |
| Website |
Collaboration and Funding
Collaborative Sites
| 1. Queen Elizabeth Hospital Birmingham Mindelsohn Way Birmingham B15 2TH UK Website |
| 2. Poole General Hospital Longfleet Road Dorset BH15 2JB UK Website |
| 3. University Hospital of Wales Heath Park Cardiff CF14 4XW UK Website |
| 4. Clatterbridge Centre for Oncology Clatterbridge Rd Birkenhead CH63 4JY UK Website |
| 5. Barnet General Hospital Wellhouse Lane London EN5 3DJ UK Website |
| 6. Frimley Park Hospital Portsmouth Rd Camberley GU16 7UJ UK Website |
| 7. St James's University Hospital Beckett Street Leeds LS9 7TF UK Website |
| 8. Christie NHS Foundation Trust 550 Wilmslow Road Manchester M20 4BX UK Website |
| 9. Freeman Hospital Freeman Road Newcastle upon Tyne NE7 7DN UK Website |
| 10. John Radcliffe Hospital Headley Way Oxford OX3 9DU UK Website |
| 11. Queen Alexandra Hospital Southwick Hill Road Portsmouth PO6 3LY UK Website |
| 12. Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital Sharoe Green Lane North Preston PR2 9HT UK Website |
| 13. University Hospital of North Tees Hardwick Road Stockton-on-Tees TS19 8PE UK Website |
| 14. Hillingdon Hospital Pield Heath Road Uxbridge UB8 3NN UK Website |
| 15. St Mary's Hospital, London Praed Street London W2 1NY UK Website |
| 16. Charing Cross Hospital Fulham Palace Rd London W6 8RF UK Website |
| 17. Aintree University Hospitals NHS Foundation Trust Longmoor Lane Liverpool L9 7AL UK Website |
| 18. Good Hope Hospital Rectory Road Sutton Coldfield B75 7RR UK Website |
| 19. Bristol Royal Infirmary Upper Maudlin Street Bristol BS2 8HW UK Website |
| 20. Cheltenham General Hospital Sandford Road Cheltenham GL53 7AN UK Website |
Additional Information
Full Research Summary| Objective: | . |
| Aim: | . |
| Methods: | . |
| Reason for International Trial: | . |