CCRinCD: Surgical Management of Colorectal Cancer in Crohn's Disease

Trial Overview

Acronym	CCRinCD
Number	NCT04654494
Protocol Link	https://www.clinicaltrials.gov/ct2/show/NCT04654494?term=sica+sensi&draw=2&rank=3
Status	Open/recruiting
Category	Colorectal Cancer - All
Treatment Course	Surgery

Trial Description

Retrospective multicentre study. All patients with a diagnosis of Crohn's disease (CD) and operated for colorectal cancer (CRC) between 01/01/2010 and 01/01/2020 will be included in the dataset. Data will include preoperative, intraoperative and postoperative variables, with long term follow up when feasible. The study will focus on a comparison between patients treated with total proctocolectomy (TPC) and patients treated with subtotal colectomy (STC) or segmental resection (SR). Prima

Chief Investigator

Giuseppe Sica
MD, PhD, Associate Professor of Surgery

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Lead Centre

Policlinico Tor Vergata
viale Oxford, 81
Roma
00133
Italia

Website

Additional Information

Full Research Summary

Objective:	Optimal management of colorectal cancer arising in Crohn's disease is uncertain. Current guidelines recommend pan-proctocolectomy (PPC) as a treatment, although evidence is scarce.
Aim:	Aim of this study was to evaluate oncologic outcomes and the actual risk of developing metachronous cancers in CD patients undergoing segmental colectomy (SC) vs extended colectomy for CRC.
Methods:	All CRC CD patients undergoing surgery between Jan 2010 and Dec 2020 will be retrospectively enrolled. Short and long-term results of SC will be compared with those of patients undergoing extended colectomies: total colectomy (TC) and panproctocolectomy (PPC). Primary outcomes: progression-free survival (PFS) and overall survival (OS). Secondary outcomes: postoperative complications, major complications, 30 days mortality, re-admission, length of stay, incidence of synchronous and metachronous lesions.
Reason for International Trial:	Colorectal cancer in Crohn's disease is a relatively rare occurrence and large numbers are welcome to provide best possible evidence.

Trial Details

CCRinCD: Surgical Management of Colorectal Cancer in Crohn's Disease

Trial Overview

Trial Description

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Lead Centre

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Trial Details

CCRinCD: Surgical Management of Colorectal Cancer in Crohn's Disease

Trial Overview

Trial Description

Chief Investigator

Lead Centre

Additional Information

Research

About ESCP

News & Events

Education

Research

Members

Contact Us

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